Leading No. 17 Syracuse by just one point at halftime, the Ducks broke open the game open in the third quarter, outscoring the Orange 31-16 en route to a convincing 81-64 win.
Clemson could lose before the College Football Playoff. It is possible. The top-ranked Tigers will play 10 more regular-season games and presumably the ACC championship game.
Creating open shots through the high post and kick-outs off drives, Baylor set a school NCAA Tournament record with 16 3-pointers to beat Syracuse 78-68 in the West Region.
Reigning national champion Villanova will be in action along with Michigan, the runner-up from a year ago, while Belmont and Murray State open the NCAA Tournament as trendy upset picks.
Williamson was electrifying, breaking a 66-year-old ACC Tournament record by going 13 of 13 from the field and scoring 29 points to propel No. 5 Duke over Syracuse 84-72.
Gonzaga remained at No. 1 after extending the nation's longest winning streak to 20 games. Virginia stayed at No. 2 after winning both its games last week.
North Carolina's Coby White shook off four games of shooting struggles to score a season-high 34 points, helping the fifth-ranked Tar Heels pull away late to beat Syracuse 93-85.