Defender Yeimar Andrade gave Seattle a first-half lead, but his own-goal early in the second half helped Minnesota United gain a 1-1 draw with the Sounders.
Cristian Espinoza scored on a first-half penalty kick and assisted on a second-half goal by Miguel Trauco to lead the San Jose Earthquakes to a 2-0 victory over the Seattle Sounders.
Seattle's Stefan Frei finished with three saves for his league-leading 10th clean sheet of the season and Pedro Gallese saved two shots as Orlando City played the Sounders to a scoreless tie.
Jeremy Ebobisse scored out of the gates in the second half and Daniel de Sousa Brito made it stand up as the San Jose Earthquakes snapped a 14-match winless skid on the road with a 1-0 victory over the Seattle Sounders.
Pedro Vite scored just before halftime and the Vancouver Whitecaps used an own-goal by Seattle goalkeeper Stefan Frei in the second half to post a 2-0 victory over the Sounders.
Erik Thommy had a goal and an assist, Alan Pulido scored his first goal in nearly two years and Sporting Kansas City stunned the Western Conference-leading Seattle Sounders with a 2-1 victory.
Brenner Souza da Silva scored in the 63rd minute and Roman Celentano made it stand up as FC Cincinnati blanked the Seattle Sounders 1-0 on Saturday night.
Jordan Morris scored his league-leading third goal of the season and Stefan Frei posted his second straight clean sheet to spark the Seattle Sounders to a 2--0 victory over Real Salt Lake.