Santana homered twice, including his first grand slam in three years, and Ty France drove in four runs as the Mariners snapped a three-game losing streak with a 9-1 victory over the Los Angeles Angels.
Kyle Seager had a two-run double in the decisive third inning among his three hits and three RBIs, Mitch Haniger added two doubles as the Seattle Mariners beat the Oakland Athletics 4-2.
Frankie Montas struck out 10 over seven scoreless innings and Oakland took advantage of some early Los Angeles miscues in Starling Marte’s debut with the Athletics and beat the Angels 4-0.
Yu Darvish became the fastest big leaguer to reach 1,500 strikeouts for his career by fanning 11. Manny Machado and Jake Cronenworth homered and the Padres beat the Dodgers 6-2.
Houston's Gerrit Cole struck out 10 batters, including his 300th of the season, Yuli Gurriel and Jose Altuve homered and the Astros beat the Texas Rangers 3-2.