(AP) — Matt Wieters homered twice, reached base five times and didn't come close to being the star of the game in the Washington Nationals' 23-5 destruction of the New York Mets.

Anthony Rendon set a team record with 10 RBIs while going 6-for-6 with three home runs and five runs scored. Rendon is the 13th player in major league history with at least 10 ribbies in a game, and the first in 10 years. His timeline was a two-run single, a solo homer, a three-run blast, a three-run double, a single and a solo shot off Mets backup catcher Kevin Plawecki.

Bryce Harper and Adam Lind also went deep off Plawecki in the eighth inning as the Nats finished with a Washington/Montreal franchise record for runs. Their seven home runs are the most since the club moved from Montreal after the 2004 season.

The Mets failed to complete a three-game sweep and finished without Noah Syndergaard, who left in the second inning with what the club called "a possible right lat strain." The Mets' ace will undergo an MRI.

Elsewhere in the majors:

— Marco Hernandez scored the go-ahead run on Pedro Strop's wild pitch in a four-run eighth that gave Boston a 6-2 victory and a series win over the Chicago Cubs. Hanley Ramirez hit a two-run homer for the Red Sox, who also scored twice on shortstop Addison Russell's throwing error in the eighth.

— Baltimore avoided a three-game sweep as Mark Trumbo hit a go-ahead single in a three-run 11th that pushed the Orioles past the New York Yankees, 7-4. Adam Jones and Welington Castillo each had three hits and an RBI for the Birds, who blew a 4-2 lead in the ninth before pulling into a tie with the Yanks for first place in the AL East.

— Michael Brantley homered and Francisco Lindor doubled home a pair while the Indians put together an eight-run third in a 12-4 assault on Seattle. Roberto Perez had three hits and drove in three runs as the defending AL champs won for the ninth time in their last 12 games.

— Dallas Keuchel is 5-0 after holding Oakland to a run and three hits while striking out nine over 7 2/3s to lead Houston's 7-2 win. Marwin Gonzalez hit a three-run homer to help Keuchel join Roger Clemens as the only Astros pitchers to win five games in April.

— Jefry Marte  homered and hit a tiebreaking, two-run single to help the Angels beat the Rangers, 5-2 in Texas. JC Ramirez struck out nine over 5 1/3 innings en route to his first win in four starts following 111 career relief appearances.

— Detroit's four-game skid is over after Jose Iglesias doubled and drove in three runs to lead the Tigers past the White Sox, 7-3. The Tigers reached Miguel Gonzalez for seven runs and a career-high 14 hits over six innings while ending Chicago's six-game winning streak.

— Minnesota dealt Kansas City its ninth straight loss as Miguel Sano belted a three-run homer and had five RBIs to lead the Twins' 7-5 victory. Sano is on an 11-for-16 hot streak and has driven in nine runs over his last two games.

— Russell Martin hit a go-ahead single during a three-run rally in the eighth that gave the Blue Jays a 3-1 triumph over Tampa Bay and their first winning streak of the season. Six Toronto relievers combined to toss one-run ball over eight innings after Aaron Sanchez left with a split fingernail.

— Daniel Descalso hit a two-run homer into the Chase Field swimming pool in the 13th inning to complete Arizona's 2-0 win over Colorado. The blast ended the longest scoreless game in stadium history and allowed the Diamondbacks to avoid a sweep.

— Andrew Toles smacked a three-run homer and the Dodgers completed a three-game sweep by topping the Phillies, 5-3 in Los Angeles. Chris Taylor also went deep to help Hyun-Jin Ryu get his first win since an 0-4 start.

— The Padres beat the Giants, 5-2 on Wil Myers' three-run homer in the top of the 12th. Former Giant Hector Sanchez provided a pinch-hit, two-run homer off closer Mark Melancon in the ninth to extend the game.

— Joey Votto hit a tiebreaking single in the eighth as Cincinnati won for just the second time in its last 10 games, 5-4 at St. Louis. Adam Duvall doubled three times and singled, including an RBI hit in a three-run seventh that tied the game 4-4.

— Justin Bour set career highs with four hits and six RBIs as the Marlins crushed the Pirates, 10-3 at Miami. Bour delivered a two-run homer in a six-run seventh that helped the Marlins end a four-game skid.

— Domingo Santana accounted for Milwaukee's runs with a pair of homers, including a three-run blast that led a 4-3 win over Atlanta. Freddie Freeman's ninth homer of the season put the Braves up 2-1 in the sixth.