DENVER (AP) -- Peyton Manning's receivers played keep-away with his milestone memento and the NFL's new leader in career touchdown passes toyed with the San Francisco 49ers in the Denver Broncos' emphatic 42-17 victory Sunday night.

Manning went into the showdown two TDs shy of Brett Favre's record of 508 and threw four touchdown passes, giving him 510.

He surpassed Favre's mark with an 8-yard strike to Demaryius Thomas late in the second quarter. As he went to retrieve the football, his teammates decided to have some fun.

Thomas tossed the historic ball over Manning and to Emmanuel Sanders, who then lobbed it to Wes Welker. From there, Welker dished it back to Sanders, who then flipped it to Julius Thomas — all of Manning's favorite targets getting into the act.

Finally, Manning got the ball along with congratulations from his teammates and coaches.

More From 1460 ESPN