PEORIA, Ariz. (AP) — Philip Humber began a comeback bid by throwing two scoreless innings for the San Diego Padres in a 6-5 loss to the Seattle Mariners on Thursday.

Facing the same club he threw a perfect game against four years ago, the 33-year-old right-hander retired the first three before working around two walks and Jesus Montero's single in the second.

Humber's 2012 perfect game with the Chicago White Sox was followed by misery. His ERA soared to 7.90 a year later with Houston, his last big-league season. He was cut from his South Korean team last year.

Nathan Karns allowed Cory Spangenberg's single and a walk in two scoreless innings in his Mariners debut.

Luis Sardinas' consecutive two-run doubles in the fifth and sixth put Seattle ahead.

Alexi Ramirez had an RBI single off Joe Wieland in his San Diego debut, ending the Padres' 11-inning scoreless streak to start Cactus League play.